Acute myeloid leukemia stem cells: seek and destroy
نویسندگان
چکیده
منابع مشابه
Multidrug resistance and stem cells in acute myeloid leukemia.
The article by Raaijmakers et al. (1) in this issue reports a provocative study with important implications for therapeutic strategies in acute myelogenous leukemia (AML). Expression of the MDR1 (ABCB1) gene, encoding the multidrug transporter P-glycoprotein (P-gp), is a major negative prognostic factor in adult patients with AMLs (2–4). Attempts to improve clinical outcomes in AML by modulatio...
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BACKGROUND The poor outcomes for patients diagnosed with acute myeloid leukemia (AML) are largely attributed to leukemia stem cells (LSCs) which are difficult to eliminate with conventional therapy and responsible for relapse. Thus, new therapeutic strategies which could selectively target LSCs in clinical leukemia treatment and avoid drug resistance are urgently needed. However, only a few sma...
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Evidence for the cancer stem cell model was first demonstrated in xenotransplanted blood and bone marrow samples from patients with acute myeloid leukemia (AML) almost two decades ago, supporting the concept that a rare clonal and mutated leukemic stem cell (LSC) population is sufficient to drive leukemic growth. The inability to eliminate LSCs with conventional therapies is thought to be the p...
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Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell production. In the absence of therapy or sometimes despite it, CML has a propensity to progress from a relatively well tolerated chronic phase to an almost uniformly fatal blast crisis phase. The discovery of the Philadelphia chromosome followed by identification of its BCR-ABL fusion gene product and th...
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Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow characterized by an uncontrolled proliferation of undifferentiated myeloid lineage cells. Decades of research have demonstrated that AML evolves from the sequential acquisition of genetic alterations within a single lineage of hematopoietic cells. More recently, the advent of high-throughput sequencing has enabled the i...
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ژورنال
عنوان ژورنال: Expert Review of Hematology
سال: 2009
ISSN: 1747-4086,1747-4094
DOI: 10.1586/ehm.09.53